The Omicron, a new variant of Sars Cov 2, was primarily responsible for the fourth and largest wave in South Africa to date. The Wuhan strain and its two variants, Beta and Delta, were responsible for the first three waves. A comparison of infection and mortality rates across all four waves confirms that the Omicron infected a large number of people in the shortest amount of time. However, it has not resulted in any deaths. To date, no deaths have been reported in South Africa as a result of Omicron. This analysis supports experts' belief that Omicron behaves like a live attenuated virus and can serve as a natural vaccine. The Wuhan strain, also known as the original Sars Co 2, caused the first wave. It began in early June and lasted until the end of August. The highest seven-day average infection and death rate were approximately 12,000 and 297, respectively. Nearly three months later, in mid-November, the country saw an increase in cases. It culminated in the second wave owing primarily to a new variant, Beta, which originated in South Africa. The highest seven-day average infection and death rates were 19042 and 510, respectively. It took nearly three months to flatten the curve and return to normalcy. This was South Africa's deadliest wave, with a high number of casualties. During mid-May, South Africa witnessed the start of the third wave. It had been almost three months since the second wave. The genome sequencing of positive patients' samples revealed that the vast majority of them were infected with the Delta variant. It lasted four months, with the highest seven-day averages of infection and death being 19184 and 305, respectively. In South Africa, the virus mutated for the second time, resulting in the emergence of a new variant known as Omicron. This triggered the fourth wave, which began on November 20 and is currently in a declining phase. The highest-seven-day average infection and death during the fourth wave were 19400 and 44, respectively. Since South Africa has not reported any confirmed deaths from Omicron, many experts believe that other variants, such as Delta, which is still present and infecting a smaller number of people.